EPSRC Network on Evolvability in Biology & Software Systems

Evolvability, Genetics & Development in Natural and Constructed Systems: Abstracts of the EPSRC Evolvability Network Symposium

Tewin Bury Farm Hotel, Hertfordshire, England, UK
26-28 August 2003

University of Hertfordshire Computer Science Technical Report 389
C. L. Nehaniv, P. J. Bentley & S. Kumar (Editors)

The Logic of Gene Regulation (POSTER)

The Logic of Gene Regulation


Biocomputation Research Laboratory
Science and Technology Research Centre - University of Hertforshire
College lane - AL10 9AB Hatfield - Hertfordshire - UK


Transcription factors (TFs) bind to target sequences on regulatory regions of genes, and determine the extent to which a gene is expressed (manifests itself) by stimulating or repressing gene transcription. TFs are gene products themselves, and their own expression levels are also subject to TF control. The multi-level regulatory networks formed by genes and TFs determine how organisms develop, and respond to stimuli. It has often been suggested that such gene networks may be modelled as networks of logic gates, and gene regulation as sequences of digital switching events. We show that the rules of combinatorial Boolean logic may indeed be used to analyze and predict the behaviour of gene regulatory systems, but only as a first approximation [1].

[1] Schilstra, M. J. and Bolouri, H. (2002) Proceedings of ICSB 2002: The Logic of Life, Karolinska Institutet, Stockholm, Sweden, Karolinska Institutet; pp 197-198.